Drug interactions
Entrectinib + Fluphenazine
Severity: Moderate
Entrectinib and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib and fluphenazine can each lengthen the QT interval, so combined use may increase the likelihood of torsades de pointes. Patients with bradycardia, electrolyte abnormalities or structural heart disease are at greater risk.
What this interaction means in plain words
Entrectinib and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization (QT interval).
What to do
Check a baseline ECG and electrolytes and repeat the ECG during co-therapy, especially after dose changes. Correct potassium and magnesium deficits and consider an alternative antipsychotic if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Fluphenazine?
MediHelp rates the interaction as moderate. Entrectinib and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib and fluphenazine can each lengthen the QT interval, so combined use may increase the likelihood of torsades de pointes. Patients with bradycardia, electrolyte abnormalities or structural heart disease are at greater risk.
How serious is the interaction between Entrectinib and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat the ECG during co-therapy, especially after dose changes. Correct potassium and magnesium deficits and consider an alternative antipsychotic if QTc rises significantly.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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