Drug interactions
Entrectinib + Fluvoxamine
Severity: Major
Entrectinib and Fluvoxamine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib is metabolized by CYP3A4 and fluvoxamine may increase its exposure. Both can prolong QT, raising arrhythmia risk, and entrectinib also causes CNS adverse effects.
What this interaction means in plain words
Entrectinib and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition raises entrectinib levels, with additive QT prolongation.
What to do
Avoid if possible or reduce the entrectinib dose per labeling. Monitor ECG and electrolytes and resume the dose after stopping the inhibitor.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Fluvoxamine?
MediHelp rates the interaction as major. Entrectinib and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib is metabolized by CYP3A4 and fluvoxamine may increase its exposure. Both can prolong QT, raising arrhythmia risk, and entrectinib also causes CNS adverse effects.
How serious is the interaction between Entrectinib and Fluvoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or reduce the entrectinib dose per labeling. Monitor ECG and electrolytes and resume the dose after stopping the inhibitor.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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