Drug interactions
Entrectinib + Gemifloxacin
Severity: Major
Entrectinib and Gemifloxacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and gemifloxacin has the same liability. Together they may produce additive QTc prolongation and raise the risk of torsades de pointes.
What this interaction means in plain words
Entrectinib and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive delayed ventricular repolarization.
What to do
Choose a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and electrolytes and correct any abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Gemifloxacin?
MediHelp rates the interaction as major. Entrectinib and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval and gemifloxacin has the same liability. Together they may produce additive QTc prolongation and raise the risk of torsades de pointes.
How serious is the interaction between Entrectinib and Gemifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and electrolytes and correct any abnormalities.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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