Drug interactions
Entrectinib + Haloperidol
Severity: Major
Entrectinib and Haloperidol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QTc interval, and haloperidol may also raise entrectinib levels through CYP3A4 inhibition. Together these effects increase the risk of arrhythmia and entrectinib toxicity.
What this interaction means in plain words
Entrectinib and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus haloperidol inhibition of CYP3A4-mediated entrectinib metabolism.
What to do
Avoid the combination if possible and use a non-QT-prolonging antipsychotic. If it cannot be avoided, monitor the ECG and electrolytes and consider reducing the entrectinib dose per labeling for moderate CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Haloperidol?
MediHelp rates the interaction as major. Entrectinib and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QTc interval, and haloperidol may also raise entrectinib levels through CYP3A4 inhibition. Together these effects increase the risk of arrhythmia and entrectinib toxicity.
How serious is the interaction between Entrectinib and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-QT-prolonging antipsychotic. If it cannot be avoided, monitor the ECG and electrolytes and consider reducing the entrectinib dose per labeling for moderate CYP3A inhibitors.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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