Drug interactions
Entrectinib + Indacaterol-glycopyrronium
Severity: Moderate
Entrectinib and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and indacaterol, a long-acting beta-agonist, may add to this effect at high exposure or when hypokalemia is present. The combination raises the risk of torsades de pointes, particularly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Entrectinib and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Check baseline ECG and correct potassium and magnesium before starting, then repeat ECGs periodically. Use an alternative bronchodilator if QTc rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Entrectinib and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and indacaterol, a long-acting beta-agonist, may add to this effect at high exposure or when hypokalemia is present. The combination raises the risk of torsades de pointes, particularly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Entrectinib and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before starting, then repeat ECGs periodically. Use an alternative bronchodilator if QTc rises markedly.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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