Drug interactions
Entrectinib + Mefloquine
Severity: Major
Entrectinib and Mefloquine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and mefloquine has a similar liability. Together they may raise the risk of torsades de pointes and other ventricular arrhythmias.
What this interaction means in plain words
Entrectinib and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid concurrent use where possible. If it cannot be avoided, monitor the ECG and electrolytes and reduce or interrupt entrectinib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Mefloquine?
MediHelp rates the interaction as major. Entrectinib and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval and mefloquine has a similar liability. Together they may raise the risk of torsades de pointes and other ventricular arrhythmias.
How serious is the interaction between Entrectinib and Mefloquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If it cannot be avoided, monitor the ECG and electrolytes and reduce or interrupt entrectinib if the QTc becomes markedly prolonged.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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