Drug interactions
Entrectinib + Moxifloxacin
Severity: Major
Entrectinib and Moxifloxacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and moxifloxacin has a recognized QT-prolonging effect. Together they increase the likelihood of torsades de pointes, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Entrectinib and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use an alternative antibiotic when possible. If combined, check baseline and follow-up ECGs and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Moxifloxacin?
MediHelp rates the interaction as major. Entrectinib and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval and moxifloxacin has a recognized QT-prolonging effect. Together they increase the likelihood of torsades de pointes, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Entrectinib and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic when possible. If combined, check baseline and follow-up ECGs and keep potassium and magnesium within normal range.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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