Drug interactions
Entrectinib + Perphenazine
Severity: Moderate
Entrectinib and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and perphenazine has similar potential. Together they increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Entrectinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG and electrolytes at baseline and during therapy. Reduce or stop the offending drug if QTc increases significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Perphenazine?
MediHelp rates the interaction as moderate. Entrectinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and perphenazine has similar potential. Together they increase the risk of ventricular arrhythmias.
How serious is the interaction between Entrectinib and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during therapy. Reduce or stop the offending drug if QTc increases significantly.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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