Drug interactions
Entrectinib + Promethazine
Severity: Major
Entrectinib and Promethazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The concomitant use of promethazine and entrectinib may lead to a significant decrease in the QTc interval, which can potentially result in cardiac arrhythmias. Caution is advised when these medications are prescribed together due to the risk of altered cardiac conduction.
What this interaction means in plain words
Entrectinib and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Promethazine belongs to Respiratory.
Why it happens
Both promethazine and entrectinib have effects on cardiac ion channels, which can influence the QT interval. Their combined use may enhance the risk of arrhythmogenic effects.
What to do
Patients receiving both drugs should be closely monitored for any signs of cardiac irregularities. If possible, consider alternative therapies to minimize the risk of QTc interval changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Promethazine?
MediHelp rates the interaction as major. Entrectinib and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The concomitant use of promethazine and entrectinib may lead to a significant decrease in the QTc interval, which can potentially result in cardiac arrhythmias. Caution is advised when these medications are prescribed together due to the risk of altered cardiac conduction.
How serious is the interaction between Entrectinib and Promethazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Patients receiving both drugs should be closely monitored for any signs of cardiac irregularities. If possible, consider alternative therapies to minimize the risk of QTc interval changes.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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