Drug interactions
Entrectinib + Tacrolimus
Severity: Major
Entrectinib and Tacrolimus: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so used together they may raise the risk of torsades de pointes. Entrectinib is a CYP3A4 substrate and weak inhibitor, which may also modestly affect tacrolimus levels.
What this interaction means in plain words
Entrectinib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Entrectinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Check a baseline ECG and electrolytes and monitor the QTc during therapy. Monitor tacrolimus trough levels and adjust as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Tacrolimus?
MediHelp rates the interaction as major. Entrectinib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, so used together they may raise the risk of torsades de pointes. Entrectinib is a CYP3A4 substrate and weak inhibitor, which may also modestly affect tacrolimus levels.
How serious is the interaction between Entrectinib and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the QTc during therapy. Monitor tacrolimus trough levels and adjust as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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