Drug interactions
Epcoritamab + Fentanyl
Severity: Moderate
Epcoritamab and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab triggers cytokine release that can temporarily suppress CYP enzymes, which may reduce fentanyl clearance and raise its concentrations. This could cause greater sedation and respiratory depression, especially around the time of cytokine release syndrome.
What this interaction means in plain words
Epcoritamab and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Fentanyl belongs to Musculoskeletal.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces fentanyl metabolism.
What to do
Monitor for opioid toxicity such as sedation and slowed breathing during and shortly after epcoritamab dosing, particularly during cytokine release. Reduce the fentanyl dose if signs of excess effect appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Fentanyl?
MediHelp rates the interaction as moderate. Epcoritamab and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab triggers cytokine release that can temporarily suppress CYP enzymes, which may reduce fentanyl clearance and raise its concentrations. This could cause greater sedation and respiratory depression, especially around the time of cytokine release syndrome.
How serious is the interaction between Epcoritamab and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for opioid toxicity such as sedation and slowed breathing during and shortly after epcoritamab dosing, particularly during cytokine release. Reduce the fentanyl dose if signs of excess effect appear.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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