Drug interactions
Epcoritamab + Olanzapine
Severity: Moderate
Epcoritamab and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab causes cytokine release that can transiently suppress CYP enzymes. Olanzapine exposure may rise, with more sedation and other dose-related adverse effects.
What this interaction means in plain words
Epcoritamab and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Olanzapine belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP1A2 metabolism of olanzapine.
What to do
Monitor for olanzapine toxicity such as excessive sedation or hypotension during epcoritamab initiation and any CRS episode. Lower the olanzapine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Epcoritamab and Olanzapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Olanzapine
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Olanzapine?
MediHelp rates the interaction as moderate. Epcoritamab and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab causes cytokine release that can transiently suppress CYP enzymes. Olanzapine exposure may rise, with more sedation and other dose-related adverse effects.
How serious is the interaction between Epcoritamab and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for olanzapine toxicity such as excessive sedation or hypotension during epcoritamab initiation and any CRS episode. Lower the olanzapine dose if adverse effects occur.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
