Drug interactions
Epcoritamab + Phenytoin
Severity: Moderate
Epcoritamab and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that can transiently suppress CYP enzymes and raise levels of narrow-therapeutic-index substrates such as phenytoin. This may result in phenytoin toxicity, especially during cytokine release syndrome.
What this interaction means in plain words
Epcoritamab and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP450 enzyme activity.
What to do
Monitor phenytoin concentrations and clinical signs of toxicity at treatment initiation and during CRS, adjusting the phenytoin dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Phenytoin?
MediHelp rates the interaction as moderate. Epcoritamab and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab induces cytokine release that can transiently suppress CYP enzymes and raise levels of narrow-therapeutic-index substrates such as phenytoin. This may result in phenytoin toxicity, especially during cytokine release syndrome.
How serious is the interaction between Epcoritamab and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin concentrations and clinical signs of toxicity at treatment initiation and during CRS, adjusting the phenytoin dose as required.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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