Drug interactions
Epcoritamab + Theophylline
Severity: Moderate
Epcoritamab and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab releases cytokines that can transiently suppress CYP enzymes and raise exposure to narrow therapeutic index substrates like theophylline. The effect is greatest around initial dosing and during CRS.
What this interaction means in plain words
Epcoritamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Cytokine release suppresses CYP-mediated theophylline metabolism.
What to do
Monitor theophylline levels and toxicity signs at the start of epcoritamab treatment and during CRS, and reduce the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Theophylline?
MediHelp rates the interaction as moderate. Epcoritamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab releases cytokines that can transiently suppress CYP enzymes and raise exposure to narrow therapeutic index substrates like theophylline. The effect is greatest around initial dosing and during CRS.
How serious is the interaction between Epcoritamab and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline levels and toxicity signs at the start of epcoritamab treatment and during CRS, and reduce the dose if needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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