Drug interactions
Ephedrine + Fluticasone-salmeterol
Severity: Moderate
Ephedrine and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine is a sympathomimetic that raises blood pressure and heart rate, and salmeterol adds beta-adrenergic cardiac stimulation. Together they may cause tachycardia, palpitations, tremor, hypertension and arrhythmia, and beta-agonists may also lower potassium.
What this interaction means in plain words
Ephedrine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive adrenergic stimulation, including beta-2-mediated potassium lowering.
What to do
Monitor blood pressure, heart rate and symptoms, and avoid combined use in patients with significant cardiovascular disease. Check potassium when higher doses are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Ephedrine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine is a sympathomimetic that raises blood pressure and heart rate, and salmeterol adds beta-adrenergic cardiac stimulation. Together they may cause tachycardia, palpitations, tremor, hypertension and arrhythmia, and beta-agonists may also lower potassium.
How serious is the interaction between Ephedrine and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and symptoms, and avoid combined use in patients with significant cardiovascular disease. Check potassium when higher doses are used.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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