Drug interactions
Ephedrine + Sacubitril-valsartan
Severity: Minor
Ephedrine and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan tends to raise serum potassium, while ephedrine has beta-adrenergic activity that can lower it slightly. The net effect is unpredictable and usually small. Ephedrine's pressor effect may also partly oppose the blood pressure lowering of sacubitril-valsartan.
What this interaction means in plain words
Ephedrine and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ephedrine belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Opposing effects on potassium distribution (renin-angiotensin blockade versus beta-adrenergic cellular uptake) and pharmacodynamic opposition of blood pressure effects.
What to do
No routine adjustment is needed; monitor blood pressure and serum potassium if ephedrine is used repeatedly or in high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Ephedrine and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan tends to raise serum potassium, while ephedrine has beta-adrenergic activity that can lower it slightly. The net effect is unpredictable and usually small. Ephedrine's pressor effect may also partly oppose the blood pressure lowering of sacubitril-valsartan.
How serious is the interaction between Ephedrine and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure and serum potassium if ephedrine is used repeatedly or in high doses.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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