Drug interactions
Ephedrine + Tolmetin
Severity: Minor
Ephedrine and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin may promote potassium retention, while ephedrine can lower serum potassium via beta-adrenergic stimulation. The net effect is unclear and rarely clinically important. NSAIDs may also modestly blunt the blood pressure response to some pressor agents.
What this interaction means in plain words
Ephedrine and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ephedrine belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
Opposing effects on serum potassium; the clinical interaction is poorly established.
What to do
No routine intervention is needed. Check potassium and blood pressure if either drug is given at high doses or to patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Tolmetin?
MediHelp rates the interaction as minor. Ephedrine and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolmetin may promote potassium retention, while ephedrine can lower serum potassium via beta-adrenergic stimulation. The net effect is unclear and rarely clinically important. NSAIDs may also modestly blunt the blood pressure response to some pressor agents.
How serious is the interaction between Ephedrine and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine intervention is needed. Check potassium and blood pressure if either drug is given at high doses or to patients with renal impairment.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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