Drug interactions
Epinephrine + Erythromycin lactobionate
Severity: Moderate
Epinephrine and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin can prolong the QT interval and cause torsades de pointes, particularly at higher infusion rates. Epinephrine may add to arrhythmic risk, mainly with systemic dosing or other risk factors.
What this interaction means in plain words
Epinephrine and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Additive QT prolongation and proarrhythmic effects.
What to do
Monitor ECG when epinephrine is used systemically and correct potassium and magnesium. Do not delay epinephrine in emergencies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Epinephrine with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Epinephrine and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin can prolong the QT interval and cause torsades de pointes, particularly at higher infusion rates. Epinephrine may add to arrhythmic risk, mainly with systemic dosing or other risk factors.
How serious is the interaction between Epinephrine and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG when epinephrine is used systemically and correct potassium and magnesium. Do not delay epinephrine in emergencies.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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