Drug interactions
Cisapride + Erythromycin lactobionate
Severity: Contraindicated
Cisapride and Erythromycin lactobionate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits cisapride metabolism and both prolong the QT interval. The combination can cause torsades de pointes and fatal ventricular arrhythmias.
What this interaction means in plain words
Cisapride and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by erythromycin raises cisapride levels, with additive QT prolongation.
What to do
Do not coadminister; use a non-QT-prolonging prokinetic or non-macrolide antibiotic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Erythromycin lactobionate
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
- Erythromycin lactobionate + Lovastatin Contraindicated
Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Frequently asked questions
Can I take Cisapride with Erythromycin lactobionate?
MediHelp rates the interaction as contraindicated. Cisapride and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin inhibits cisapride metabolism and both prolong the QT interval. The combination can cause torsades de pointes and fatal ventricular arrhythmias.
How serious is the interaction between Cisapride and Erythromycin lactobionate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-QT-prolonging prokinetic or non-macrolide antibiotic.
What other medicines interact with Erythromycin lactobionate?
MediHelp also lists interactions of Erythromycin lactobionate with, for example, Dihydroergotamine, Dronedarone, Eletriptan. The full list is on the Erythromycin lactobionate page.
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