Drug interactions
Erythromycin lactobionate + Flibanserin
Severity: Contraindicated
Erythromycin lactobionate and Flibanserin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and can raise flibanserin concentrations. The result may be severe hypotension, syncope and sedation.
What this interaction means in plain words
Erythromycin lactobionate and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Erythromycin lactobionate belongs to Anti Bacterial; Flibanserin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 reduces flibanserin clearance.
What to do
Avoid; hold flibanserin during erythromycin therapy or use a non-inhibiting antibiotic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Lovastatin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Flibanserin?
MediHelp rates the interaction as contraindicated. Erythromycin lactobionate and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intravenous erythromycin inhibits CYP3A4 and can raise flibanserin concentrations. The result may be severe hypotension, syncope and sedation.
How serious is the interaction between Erythromycin lactobionate and Flibanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; hold flibanserin during erythromycin therapy or use a non-inhibiting antibiotic.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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