Drug interactions
Eletriptan + Erythromycin lactobionate
Severity: Contraindicated
Eletriptan and Erythromycin lactobionate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and substantially increases eletriptan concentrations and half-life. The result may be exaggerated vasoconstriction with cardiovascular and hypertensive risk.
What this interaction means in plain words
Eletriptan and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eletriptan belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of eletriptan.
What to do
Do not use eletriptan within 72 hours of erythromycin. Consider another antibiotic such as azithromycin or another triptan.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
- Erythromycin lactobionate + Lovastatin Contraindicated
Frequently asked questions
Can I take Eletriptan with Erythromycin lactobionate?
MediHelp rates the interaction as contraindicated. Eletriptan and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intravenous erythromycin inhibits CYP3A4 and substantially increases eletriptan concentrations and half-life. The result may be exaggerated vasoconstriction with cardiovascular and hypertensive risk.
How serious is the interaction between Eletriptan and Erythromycin lactobionate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use eletriptan within 72 hours of erythromycin. Consider another antibiotic such as azithromycin or another triptan.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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