Drug interactions
Epinephrine + Fenfluramine
Severity: Moderate
Epinephrine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a serotonin-releasing agent with some sympathomimetic effects, and epinephrine may add to cardiovascular stimulation. Increases in blood pressure and heart rate are possible, though the clinical evidence is limited.
What this interaction means in plain words
Epinephrine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Fenfluramine belongs to Central Nervous System.
Why it happens
Possible additive sympathomimetic effects; the mechanism is mostly inferred from pharmacology.
What to do
Monitor blood pressure and heart rate when epinephrine is given to a patient taking fenfluramine. Use the lowest effective epinephrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Epinephrine with Fenfluramine?
MediHelp rates the interaction as moderate. Epinephrine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine is a serotonin-releasing agent with some sympathomimetic effects, and epinephrine may add to cardiovascular stimulation. Increases in blood pressure and heart rate are possible, though the clinical evidence is limited.
How serious is the interaction between Epinephrine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when epinephrine is given to a patient taking fenfluramine. Use the lowest effective epinephrine dose.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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