Drug interactions
Epinephrine + Fluconazole
Severity: Moderate
Epinephrine and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine may prolong the QT interval at high or systemic doses, adding to the effect of fluconazole. The concern is relevant mainly for systemic or high-dose use, not for routine local anesthetic doses.
What this interaction means in plain words
Epinephrine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation and catecholamine-driven arrhythmogenic effects.
What to do
Monitor the ECG during systemic epinephrine use and correct potassium and magnesium. No change is typically required for epinephrine in local anesthetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Fluconazole?
MediHelp rates the interaction as moderate. Epinephrine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine may prolong the QT interval at high or systemic doses, adding to the effect of fluconazole. The concern is relevant mainly for systemic or high-dose use, not for routine local anesthetic doses.
How serious is the interaction between Epinephrine and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG during systemic epinephrine use and correct potassium and magnesium. No change is typically required for epinephrine in local anesthetics.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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