Drug interactions
Epinephrine + Indacaterol
Severity: Moderate
Epinephrine and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine is a potent adrenergic agonist, and combining it with indacaterol can intensify tachycardia, arrhythmia, hypertension and hypokalemia. The risk is greater in patients with heart disease.
What this interaction means in plain words
Epinephrine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Indacaterol belongs to Respiratory.
Why it happens
Additive stimulation of beta adrenergic receptors and associated potassium shift.
What to do
Epinephrine should not be withheld in anaphylaxis or cardiac arrest. Otherwise monitor ECG, blood pressure and potassium, and avoid additional inhaled beta-agonist doses during acute epinephrine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Epinephrine and Indacaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indacaterol
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Indacaterol?
MediHelp rates the interaction as moderate. Epinephrine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine is a potent adrenergic agonist, and combining it with indacaterol can intensify tachycardia, arrhythmia, hypertension and hypokalemia. The risk is greater in patients with heart disease.
How serious is the interaction between Epinephrine and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Epinephrine should not be withheld in anaphylaxis or cardiac arrest. Otherwise monitor ECG, blood pressure and potassium, and avoid additional inhaled beta-agonist doses during acute epinephrine use.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
