Drug interactions
Epinephrine + Insulin degludec-insulin aspart
Severity: Moderate
Epinephrine and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine raises blood glucose and can reduce the effectiveness of insulin. The effect is usually temporary but may be significant with systemic or repeated dosing.
What this interaction means in plain words
Epinephrine and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: epinephrine stimulates glycogenolysis and gluconeogenesis and inhibits insulin secretion.
What to do
Monitor blood glucose after systemic epinephrine and adjust insulin as needed. Expect the effect to resolve when epinephrine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Epinephrine and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine raises blood glucose and can reduce the effectiveness of insulin. The effect is usually temporary but may be significant with systemic or repeated dosing.
How serious is the interaction between Epinephrine and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after systemic epinephrine and adjust insulin as needed. Expect the effect to resolve when epinephrine is stopped.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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