Drug interactions
Epinephrine + Levoketoconazole
Severity: Moderate
Epinephrine and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole prolongs the QT interval and can cause torsades de pointes. Epinephrine adds proarrhythmic stimulation and may lower potassium, increasing the risk.
What this interaction means in plain words
Epinephrine and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Additive QT prolongation and proarrhythmic effects.
What to do
Obtain a baseline ECG and monitor it when systemic epinephrine is needed, keeping potassium and magnesium normal. Do not withhold epinephrine in emergencies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Epinephrine with Levoketoconazole?
MediHelp rates the interaction as moderate. Epinephrine and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole prolongs the QT interval and can cause torsades de pointes. Epinephrine adds proarrhythmic stimulation and may lower potassium, increasing the risk.
How serious is the interaction between Epinephrine and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it when systemic epinephrine is needed, keeping potassium and magnesium normal. Do not withhold epinephrine in emergencies.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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