Drug interactions
Epinephrine + Modafinil
Severity: Moderate
Epinephrine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have stimulant or sympathomimetic effects, so together they may increase heart rate and blood pressure and cause palpitations or arrhythmias. The risk is mainly relevant with systemic epinephrine and in patients with cardiovascular disease.
What this interaction means in plain words
Epinephrine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Modafinil belongs to Central Nervous System.
Why it happens
Additive sympathomimetic and CNS stimulant effects.
What to do
Monitor blood pressure, heart rate and ECG when systemic epinephrine is given to patients on modafinil; do not withhold epinephrine in anaphylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Modafinil?
MediHelp rates the interaction as moderate. Epinephrine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have stimulant or sympathomimetic effects, so together they may increase heart rate and blood pressure and cause palpitations or arrhythmias. The risk is mainly relevant with systemic epinephrine and in patients with cardiovascular disease.
How serious is the interaction between Epinephrine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when systemic epinephrine is given to patients on modafinil; do not withhold epinephrine in anaphylaxis.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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