Drug interactions
Epinephrine + Opicapone
Severity: Moderate
Epinephrine and Opicapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opicapone inhibits COMT, one of the enzymes that metabolize catecholamines, so it may raise and prolong epinephrine exposure. This can increase heart rate, blood pressure and arrhythmia risk, especially with systemic epinephrine.
What this interaction means in plain words
Epinephrine and Opicapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Opicapone belongs to Central Nervous System.
Why it happens
Inhibition of COMT-mediated catecholamine metabolism.
What to do
Monitor heart rate, rhythm and blood pressure when systemic epinephrine is needed in patients on opicapone. Use the lowest effective epinephrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Opicapone
- Isocarboxazid + Opicapone Contraindicated
- Opicapone + Phenelzine Contraindicated
- Opicapone + Tranylcypromine Contraindicated
- Adrenaline-articaine + Opicapone Moderate
- Asenapine + Opicapone Moderate
- Dobutamine + Opicapone Moderate
Frequently asked questions
Can I take Epinephrine with Opicapone?
MediHelp rates the interaction as moderate. Epinephrine and Opicapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opicapone inhibits COMT, one of the enzymes that metabolize catecholamines, so it may raise and prolong epinephrine exposure. This can increase heart rate, blood pressure and arrhythmia risk, especially with systemic epinephrine.
How serious is the interaction between Epinephrine and Opicapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure when systemic epinephrine is needed in patients on opicapone. Use the lowest effective epinephrine dose.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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