Drug interactions
Asenapine + Opicapone
Severity: Moderate
Asenapine and Opicapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opicapone is a COMT inhibitor used in Parkinson disease and is not a meaningful sedative, though somnolence is reported. Asenapine, a dopamine antagonist, may also oppose the antiparkinsonian effect of dopaminergic therapy.
What this interaction means in plain words
Asenapine and Opicapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Opicapone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of dopaminergic therapy by asenapine, with possible additive somnolence.
What to do
Monitor for worsening parkinsonian motor symptoms and for somnolence. If an antipsychotic is needed in Parkinson disease, prefer quetiapine or clozapine over asenapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Asenapine and Opicapone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Opicapone
- Isocarboxazid + Opicapone Contraindicated
- Opicapone + Phenelzine Contraindicated
- Opicapone + Tranylcypromine Contraindicated
- Adrenaline-articaine + Opicapone Moderate
- Dobutamine + Opicapone Moderate
- Dopamine + Opicapone Moderate
Frequently asked questions
Can I take Asenapine with Opicapone?
MediHelp rates the interaction as moderate. Asenapine and Opicapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opicapone is a COMT inhibitor used in Parkinson disease and is not a meaningful sedative, though somnolence is reported. Asenapine, a dopamine antagonist, may also oppose the antiparkinsonian effect of dopaminergic therapy.
How serious is the interaction between Asenapine and Opicapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening parkinsonian motor symptoms and for somnolence. If an antipsychotic is needed in Parkinson disease, prefer quetiapine or clozapine over asenapine.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
