Drug interactions
Opicapone + Tranylcypromine
Severity: Contraindicated
Opicapone and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opicapone inhibits COMT, and with a nonselective MAO inhibitor both main catecholamine pathways are blocked. This can cause marked increases in heart rate and blood pressure. Labeling contraindicates use with nonselective MAOIs.
What this interaction means in plain words
Opicapone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Opicapone belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Combined inhibition of COMT and MAO prevents catecholamine metabolism, causing excess catecholamines.
What to do
Do not co-administer. Choose an alternative antiparkinsonian adjunct if tranylcypromine is required.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Opicapone
- Isocarboxazid + Opicapone Contraindicated
- Opicapone + Phenelzine Contraindicated
- Adrenaline-articaine + Opicapone Moderate
- Asenapine + Opicapone Moderate
- Dobutamine + Opicapone Moderate
- Dopamine + Opicapone Moderate
Frequently asked questions
Can I take Opicapone with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Opicapone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opicapone inhibits COMT, and with a nonselective MAO inhibitor both main catecholamine pathways are blocked. This can cause marked increases in heart rate and blood pressure. Labeling contraindicates use with nonselective MAOIs.
How serious is the interaction between Opicapone and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an alternative antiparkinsonian adjunct if tranylcypromine is required.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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