Drug interactions
Isocarboxazid + Opicapone
Severity: Contraindicated
Isocarboxazid and Opicapone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opicapone reduces catecholamine breakdown through COMT inhibition, which together with nonselective MAO inhibition may cause excessive catecholamine levels. This could result in tachycardia and hypertensive crisis.
What this interaction means in plain words
Isocarboxazid and Opicapone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Opicapone belongs to Central Nervous System.
Why it happens
Simultaneous inhibition of both major catecholamine-metabolising pathways (MAO and COMT).
What to do
Avoid concurrent use as labeled for nonselective MAO inhibitors; choose another antidepressant or antiparkinsonian approach.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Opicapone
- Opicapone + Phenelzine Contraindicated
- Opicapone + Tranylcypromine Contraindicated
- Adrenaline-articaine + Opicapone Moderate
- Asenapine + Opicapone Moderate
- Dobutamine + Opicapone Moderate
- Dopamine + Opicapone Moderate
Frequently asked questions
Can I take Isocarboxazid with Opicapone?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Opicapone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opicapone reduces catecholamine breakdown through COMT inhibition, which together with nonselective MAO inhibition may cause excessive catecholamine levels. This could result in tachycardia and hypertensive crisis.
How serious is the interaction between Isocarboxazid and Opicapone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as labeled for nonselective MAO inhibitors; choose another antidepressant or antiparkinsonian approach.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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