Drug interactions
Opicapone + Phenelzine
Severity: Contraindicated
Opicapone and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opicapone inhibits COMT, and nonselective MAO inhibition blocks the other main route of catecholamine breakdown. Inhibiting both pathways may cause dangerous increases in blood pressure and heart rate. Opicapone labeling contraindicates nonselective MAOIs.
What this interaction means in plain words
Opicapone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Opicapone belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Concurrent inhibition of COMT and MAO prevents catecholamine metabolism and causes accumulation.
What to do
Do not use together. Choose an alternative antidepressant in patients taking opicapone.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Opicapone
- Isocarboxazid + Opicapone Contraindicated
- Opicapone + Tranylcypromine Contraindicated
- Adrenaline-articaine + Opicapone Moderate
- Asenapine + Opicapone Moderate
- Dobutamine + Opicapone Moderate
- Dopamine + Opicapone Moderate
Frequently asked questions
Can I take Opicapone with Phenelzine?
MediHelp rates the interaction as contraindicated. Opicapone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opicapone inhibits COMT, and nonselective MAO inhibition blocks the other main route of catecholamine breakdown. Inhibiting both pathways may cause dangerous increases in blood pressure and heart rate. Opicapone labeling contraindicates nonselective MAOIs.
How serious is the interaction between Opicapone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose an alternative antidepressant in patients taking opicapone.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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