Drug interactions
Epinephrine + Propylhexedrine
Severity: Moderate
Epinephrine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant with vasoconstrictor action. Combined with epinephrine it may add to hypertension, tachycardia and arrhythmia risk, especially when misused or in patients with cardiovascular disease.
What this interaction means in plain words
Epinephrine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Propylhexedrine belongs to Respiratory.
Why it happens
Additive adrenergic stimulation.
What to do
Monitor blood pressure and heart rate when epinephrine is needed in patients using propylhexedrine. Advise cardiac patients to avoid overuse of the inhaler.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Epinephrine with Propylhexedrine?
MediHelp rates the interaction as moderate. Epinephrine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is an inhaled sympathomimetic decongestant with vasoconstrictor action. Combined with epinephrine it may add to hypertension, tachycardia and arrhythmia risk, especially when misused or in patients with cardiovascular disease.
How serious is the interaction between Epinephrine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when epinephrine is needed in patients using propylhexedrine. Advise cardiac patients to avoid overuse of the inhaler.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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