Drug interactions
Linezolid + Propylhexedrine
Severity: Major
Linezolid and Propylhexedrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a reversible, nonselective MAO inhibitor, and propylhexedrine is an indirect-acting sympathomimetic that releases norepinephrine. Together they may cause a sharp, potentially dangerous rise in blood pressure, with headache and risk of hypertensive crisis.
What this interaction means in plain words
Linezolid and Propylhexedrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Propylhexedrine belongs to Respiratory.
Why it happens
MAO inhibition by linezolid blocks catecholamine breakdown, enhancing the pressor effect of norepinephrine released by propylhexedrine.
What to do
Avoid propylhexedrine inhaler use during linezolid therapy and use a non-sympathomimetic decongestant alternative. If unavoidable, monitor blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
- Budesonide-formoterol + Propylhexedrine Moderate
Frequently asked questions
Can I take Linezolid with Propylhexedrine?
MediHelp rates the interaction as major. Linezolid and Propylhexedrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid is a reversible, nonselective MAO inhibitor, and propylhexedrine is an indirect-acting sympathomimetic that releases norepinephrine. Together they may cause a sharp, potentially dangerous rise in blood pressure, with headache and risk of hypertensive crisis.
How serious is the interaction between Linezolid and Propylhexedrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propylhexedrine inhaler use during linezolid therapy and use a non-sympathomimetic decongestant alternative. If unavoidable, monitor blood pressure closely.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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