Drug interactions
Propylhexedrine + Selegiline
Severity: Major
Propylhexedrine and Selegiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant, and MAO inhibitors can potentiate its pressor effects. A hypertensive episode is possible, particularly with non-selective MAO inhibition from transdermal selegiline or with overuse.
What this interaction means in plain words
Propylhexedrine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propylhexedrine belongs to Respiratory; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition increases stores of norepinephrine, so indirect sympathomimetic release by propylhexedrine yields an exaggerated pressor response.
What to do
Avoid propylhexedrine in patients on selegiline and use saline or non-sympathomimetic nasal measures. Monitor blood pressure if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
- Budesonide-formoterol + Propylhexedrine Moderate
Frequently asked questions
Can I take Propylhexedrine with Selegiline?
MediHelp rates the interaction as major. Propylhexedrine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propylhexedrine is an inhaled sympathomimetic decongestant, and MAO inhibitors can potentiate its pressor effects. A hypertensive episode is possible, particularly with non-selective MAO inhibition from transdermal selegiline or with overuse.
How serious is the interaction between Propylhexedrine and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propylhexedrine in patients on selegiline and use saline or non-sympathomimetic nasal measures. Monitor blood pressure if exposure occurs.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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