Drug interactions
Isocarboxazid + Propylhexedrine
Severity: Contraindicated
Isocarboxazid and Propylhexedrine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine, an inhaled decongestant with sympathomimetic activity, can provoke a hypertensive reaction in patients on MAO inhibitors. Systemic absorption is possible with misuse or heavy use.
What this interaction means in plain words
Isocarboxazid and Propylhexedrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Indirect sympathomimetic noradrenaline release amplified by MAO inhibition.
What to do
Avoid the combination and recommend saline or other non-sympathomimetic nasal measures.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Propylhexedrine
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
- Budesonide-formoterol + Propylhexedrine Moderate
Frequently asked questions
Can I take Isocarboxazid with Propylhexedrine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Propylhexedrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Propylhexedrine, an inhaled decongestant with sympathomimetic activity, can provoke a hypertensive reaction in patients on MAO inhibitors. Systemic absorption is possible with misuse or heavy use.
How serious is the interaction between Isocarboxazid and Propylhexedrine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and recommend saline or other non-sympathomimetic nasal measures.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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