Drug interactions
Propylhexedrine + Tranylcypromine
Severity: Major
Propylhexedrine and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant that releases norepinephrine. With MAO inhibition, excessive pressor responses and hypertensive crisis may occur, especially with overuse.
What this interaction means in plain words
Propylhexedrine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propylhexedrine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
Indirect sympathomimetic activity combined with blocked catecholamine metabolism from MAO inhibition.
What to do
Avoid the inhaler during tranylcypromine therapy and for 14 days afterward. Use saline or another non-sympathomimetic option for congestion.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Adrenaline-articaine + Propylhexedrine Moderate
- Budesonide-formoterol + Propylhexedrine Moderate
Frequently asked questions
Can I take Propylhexedrine with Tranylcypromine?
MediHelp rates the interaction as major. Propylhexedrine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propylhexedrine is an inhaled sympathomimetic decongestant that releases norepinephrine. With MAO inhibition, excessive pressor responses and hypertensive crisis may occur, especially with overuse.
How serious is the interaction between Propylhexedrine and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the inhaler during tranylcypromine therapy and for 14 days afterward. Use saline or another non-sympathomimetic option for congestion.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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