Drug interactions
Epinephrine + Tiotropium-olodaterol
Severity: Moderate
Epinephrine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine is a potent adrenergic agonist and its cardiovascular effects add to those of olodaterol. Tachycardia, hypertension, arrhythmias and tremor may be more pronounced.
What this interaction means in plain words
Epinephrine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive stimulation of beta and alpha adrenergic receptors.
What to do
Monitor heart rate, rhythm and blood pressure after epinephrine administration. Do not withhold epinephrine in anaphylaxis, but monitor closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Epinephrine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine is a potent adrenergic agonist and its cardiovascular effects add to those of olodaterol. Tachycardia, hypertension, arrhythmias and tremor may be more pronounced.
How serious is the interaction between Epinephrine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure after epinephrine administration. Do not withhold epinephrine in anaphylaxis, but monitor closely.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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