Drug interactions
Epinephrine + Trazodone
Severity: Moderate
Epinephrine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has alpha-adrenergic blocking activity and can alter the pressor response to epinephrine, causing unpredictable hypotension or tachycardia. Both drugs may also affect cardiac rhythm.
What this interaction means in plain words
Epinephrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Alpha-1 blockade by trazodone modifies adrenergic responses, with additive arrhythmogenic potential.
What to do
Monitor blood pressure and heart rhythm when epinephrine is given therapeutically. In anaphylaxis, give epinephrine as indicated and monitor closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Trazodone?
MediHelp rates the interaction as moderate. Epinephrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has alpha-adrenergic blocking activity and can alter the pressor response to epinephrine, causing unpredictable hypotension or tachycardia. Both drugs may also affect cardiac rhythm.
How serious is the interaction between Epinephrine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rhythm when epinephrine is given therapeutically. In anaphylaxis, give epinephrine as indicated and monitor closely.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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