Drug interactions
Epinephrine inhaled + Sotalol
Severity: Moderate
Epinephrine inhaled and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a nonselective beta-blocker and can blunt the bronchodilator effect of inhaled epinephrine, and may provoke bronchospasm in susceptible patients. Unopposed alpha effects can produce hypertension.
What this interaction means in plain words
Epinephrine inhaled and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 receptor blockade antagonizes epinephrine-induced bronchodilation.
What to do
Monitor respiratory status and blood pressure, and consider alternative therapy in patients with reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Epinephrine inhaled with Sotalol?
MediHelp rates the interaction as moderate. Epinephrine inhaled and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol is a nonselective beta-blocker and can blunt the bronchodilator effect of inhaled epinephrine, and may provoke bronchospasm in susceptible patients. Unopposed alpha effects can produce hypertension.
How serious is the interaction between Epinephrine inhaled and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and blood pressure, and consider alternative therapy in patients with reactive airway disease.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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