Drug interactions
Epinephrine racemic + Hydrochlorothiazide-irbesartan
Severity: Minor
Epinephrine racemic and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can lower serum potassium through beta-2 stimulation, which may add to thiazide-induced hypokalemia and raise arrhythmia risk. Its pressor effect may also counter antihypertensive therapy.
What this interaction means in plain words
Epinephrine racemic and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2-mediated intracellular potassium shift on top of thiazide renal potassium loss.
What to do
Monitor serum potassium and ECG when repeated or high doses of epinephrine are given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Epinephrine racemic with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Epinephrine racemic and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine can lower serum potassium through beta-2 stimulation, which may add to thiazide-induced hypokalemia and raise arrhythmia risk. Its pressor effect may also counter antihypertensive therapy.
How serious is the interaction between Epinephrine racemic and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG when repeated or high doses of epinephrine are given.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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