Drug interactions
Epinephrine racemic + Metolazone
Severity: Moderate
Epinephrine racemic and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can drive potassium into cells and, with metolazone's potassium loss, may produce additive hypokalemia, mainly with repeated or high doses. Hypokalemia can raise the risk of arrhythmia.
What this interaction means in plain words
Epinephrine racemic and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 adrenergic potassium shift adds to metolazone-induced renal potassium wasting.
What to do
Monitor serum potassium with repeated dosing and correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Epinephrine racemic with Metolazone?
MediHelp rates the interaction as moderate. Epinephrine racemic and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can drive potassium into cells and, with metolazone's potassium loss, may produce additive hypokalemia, mainly with repeated or high doses. Hypokalemia can raise the risk of arrhythmia.
How serious is the interaction between Epinephrine racemic and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium with repeated dosing and correct hypokalemia promptly.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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