Drug interactions
Epinephrine racemic + Midodrine
Severity: Moderate
Epinephrine racemic and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine has adrenergic agonist activity and may add to the pressor effect of midodrine. Systemic absorption from inhaled use is limited but can still raise blood pressure and heart rate in susceptible patients.
What this interaction means in plain words
Epinephrine racemic and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic alpha- and beta-adrenergic stimulation.
What to do
Monitor blood pressure and heart rate, particularly supine blood pressure, when used together. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Epinephrine racemic with Midodrine?
MediHelp rates the interaction as moderate. Epinephrine racemic and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine has adrenergic agonist activity and may add to the pressor effect of midodrine. Systemic absorption from inhaled use is limited but can still raise blood pressure and heart rate in susceptible patients.
How serious is the interaction between Epinephrine racemic and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly supine blood pressure, when used together. Use the lowest effective doses.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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