Drug interactions
Epinephrine racemic + Mirtazapine
Severity: Minor
Epinephrine racemic and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine, usually given by inhalation, has limited systemic exposure at standard doses. Mirtazapine enhances noradrenergic transmission, so a small additive effect on heart rate and blood pressure is theoretically possible, but significant interactions are not well documented.
What this interaction means in plain words
Epinephrine racemic and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive adrenergic effects; mirtazapine blocks alpha-2 autoreceptors and epinephrine stimulates adrenergic receptors.
What to do
No dose change is generally needed; observe heart rate and blood pressure in patients with cardiovascular disease. Reassess if palpitations or hypertension occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Mirtazapine?
MediHelp rates the interaction as minor. Epinephrine racemic and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Racemic epinephrine, usually given by inhalation, has limited systemic exposure at standard doses. Mirtazapine enhances noradrenergic transmission, so a small additive effect on heart rate and blood pressure is theoretically possible, but significant interactions are not well documented.
How serious is the interaction between Epinephrine racemic and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; observe heart rate and blood pressure in patients with cardiovascular disease. Reassess if palpitations or hypertension occur.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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