Drug interactions
Epinephrine racemic + Trazodone
Severity: Moderate
Epinephrine racemic and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine may add to QT effects and trazodone's alpha-blockade can alter the pressor response, so heart rate and blood pressure may be unpredictable. Arrhythmia and hypotension are possible, though racemic epinephrine is often given by inhalation with limited systemic exposure.
What this interaction means in plain words
Epinephrine racemic and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic interaction through alpha-adrenergic blockade and possible additive effects on cardiac repolarization.
What to do
Monitor heart rate, blood pressure and rhythm when systemic doses are used. Use the lowest effective epinephrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Epinephrine racemic and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Trazodone?
MediHelp rates the interaction as moderate. Epinephrine racemic and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine may add to QT effects and trazodone's alpha-blockade can alter the pressor response, so heart rate and blood pressure may be unpredictable. Arrhythmia and hypotension are possible, though racemic epinephrine is often given by inhalation with limited systemic exposure.
How serious is the interaction between Epinephrine racemic and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and rhythm when systemic doses are used. Use the lowest effective epinephrine dose.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
