Drug interactions
Eplerenone + Fludrocortisone
Severity: Moderate
Eplerenone and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is a mineralocorticoid agonist and directly opposes eplerenone, causing sodium retention and potassium loss. The two drugs have opposing pharmacologic effects, so efficacy of each is reduced.
What this interaction means in plain words
Eplerenone and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eplerenone belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism at the mineralocorticoid receptor.
What to do
Avoid combining unless there is a specific indication. If used together, monitor blood pressure, fluid status and serum potassium and adjust doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Eplerenone with Fludrocortisone?
MediHelp rates the interaction as moderate. Eplerenone and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone is a mineralocorticoid agonist and directly opposes eplerenone, causing sodium retention and potassium loss. The two drugs have opposing pharmacologic effects, so efficacy of each is reduced.
How serious is the interaction between Eplerenone and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless there is a specific indication. If used together, monitor blood pressure, fluid status and serum potassium and adjust doses.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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