Drug interactions
eplerenone + ketoconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ eplerenone exposure; contraindicated in label.
Mechanism of action
Strong CYP3A4 inhibition.
Clinical management
Contraindicated.
Drug reference
References
Frequently asked questions
Can I take eplerenone with ketoconazole?
The interaction is rated: Contraindicated. ↑ eplerenone exposure; contraindicated in label.
How serious is the interaction between eplerenone and ketoconazole?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between eplerenone and ketoconazole managed?
Contraindicated.
Why do eplerenone and ketoconazole interact?
Strong CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.