Drug interactions
Eplerenone + Larotrectinib
Severity: Minor
Eplerenone and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a substrate of CYP3A4 and a possible weak CYP3A4 inhibitor, so an increase in eplerenone exposure is theoretically possible. Clinical data are lacking and the effect is likely small.
What this interaction means in plain words
Eplerenone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eplerenone belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4; the effect on eplerenone is not well established.
What to do
No dose change is generally needed. Monitor serum potassium and blood pressure during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eplerenone and Larotrectinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Eplerenone with Larotrectinib?
MediHelp rates the interaction as minor. Eplerenone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a substrate of CYP3A4 and a possible weak CYP3A4 inhibitor, so an increase in eplerenone exposure is theoretically possible. Clinical data are lacking and the effect is likely small.
How serious is the interaction between Eplerenone and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor serum potassium and blood pressure during co-therapy.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
