Drug interactions
Eplerenone + Nifedipine
Severity: Minor
Eplerenone and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a CYP3A4 substrate with at most weak inhibitory effect, and no clinically meaningful rise in eplerenone exposure is established. The combination is commonly used, with additive blood pressure lowering being the main consideration.
What this interaction means in plain words
Eplerenone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eplerenone belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 competition; additive antihypertensive effect.
What to do
Monitor blood pressure when starting or adjusting either drug. No eplerenone dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eplerenone and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Eplerenone with Nifedipine?
MediHelp rates the interaction as minor. Eplerenone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a CYP3A4 substrate with at most weak inhibitory effect, and no clinically meaningful rise in eplerenone exposure is established. The combination is commonly used, with additive blood pressure lowering being the main consideration.
How serious is the interaction between Eplerenone and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or adjusting either drug. No eplerenone dose change is usually needed.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
