Drug interactions
Eplerenone + Nilotinib
Severity: Moderate
Eplerenone and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a CYP3A4 inhibitor and may raise eplerenone concentrations, increasing hyperkalemia risk. Nilotinib also prolongs the QT interval, and electrolyte disturbances such as potassium changes matter in this setting.
What this interaction means in plain words
Eplerenone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eplerenone belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated eplerenone metabolism by nilotinib.
What to do
Monitor serum potassium and ECG as appropriate during combined therapy. Reduce the eplerenone dose if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Eplerenone with Nilotinib?
MediHelp rates the interaction as moderate. Eplerenone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a CYP3A4 inhibitor and may raise eplerenone concentrations, increasing hyperkalemia risk. Nilotinib also prolongs the QT interval, and electrolyte disturbances such as potassium changes matter in this setting.
How serious is the interaction between Eplerenone and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG as appropriate during combined therapy. Reduce the eplerenone dose if potassium rises.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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